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Test Code AACSFM Amino Acids, Quantitative, Spinal Fluid

Additional Codes

Mayo AACSF
Epic ID LAB5111

 

Specimen Type

CSF


Additional Testing Requirements


This test should be ordered in conjunction with AAQP / Amino Acids, Quantitative, Plasma. The specimens for both tests (AAQP / Amino Acids, Quantitative, Plasma and this test) should be collected at the same time.



Necessary Information


1. Patient's age is required.

2. Include family history, clinical condition (asymptomatic or acute episode), diet, and drug therapy information



Specimen Required


Container/Tube: Sterile vial

Specimen Volume: 0.2 mL

Collection Instructions: Collect specimen from second collection vial.


Specimen Minimum Volume

0.1 mL

Specimen Stability Information

Specimen Type Temperature Time
CSF Frozen 14 days
UPH Waterloo Region Lab Test Catalog Note:

Transport frozen.

Reject Due To

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Portions of this test are covered by patents held by Quest Diagnostics

Testing Algorithm

Testing includes quantitation of the following amino acids: taurine, threonine, serine, hydroxyproline, asparagine, glutamic acid, 1-methylhistidine, 3-methylhistidine, argininosuccinic acid, homocitrulline, alpha-aminoadipic acid, gamma-amino-n-butyric acid, beta-aminoisobutyric acid, alpha-amino-n-butyric acid, hydroxylysine, glutamine, aspartic acid, ethanolamine, proline, glycine, alanine, citrulline, sarcosine, beta-alanine, alpha-amino-n-butyric acid, valine, cystine, methionine, isoleucine, leucine, tyrosine, phenylalanine, ornithine, cystathionine, tryptophan, allo-isoleucine, lysine, histidine, and arginine.

 

For more information see Epilepsy: Unexplained Refractory and/or Familial Testing Algorithm.

Useful For

Evaluating patients with possible inborn errors of amino acid metabolism, particularly nonketotic hyperglycinemia (glycine encephalopathy) and serine biosynthesis defects, especially when used in conjunction with concomitantly collected plasma specimens

Day(s) Performed

Monday through Friday

Reference Values

Amino Acid

≤31 days

32 days-23 months

2-18 years

≥19 years

Taurine (Tau)

8-28

4-13

4-10

3-9

Asparagine (Asn)

7-25

5-17

4-12

5-14

Serine (Ser)

43-127

37-87

22-57

18-58

Hydroxyproline (Hyp)

<12

<8

<3

<3

Glycine (Gly)

<60

<27

<20

<28

Glutamine (Gln)

447-1547

384-716

375-770

452-1283

Aspartic Acid (Asp)

<12

<12

<12

<12

Ethanolamine (EtN)

11-152

6-41

7-25

6-24

Histidine (His)

19-63

12-32

9-26

12-36

Threonine (Thr)

35-212

19-89

13-51

13-57

Citrulline (Cit)

<6

<5

<4

<4

Sarcosine (Sar)

<21

<21

<21

<21

Beta-alanine (bAla)

<17

<17

<17

<17

Alanine (Ala)

20-92

18-69

16-54

22-80

Glutamic Acid (Glu)

<12

<4

<3

<2

1-Methylhistidine (1MHis)

<5

<1

<1

<3

3-Methylhistidine (3MHis)

<4

<1

<3

<5

Argininosuccinic Acid (Asa)

<4

<4

<4

<4

Homocitrulline (Hcit)

<1

<1

<1

<1

Arginine (Arg)

7-37

11-36

13-30

14-32

Alpha-aminoadipic Acid (Aad)

<2

<2

<2

<2

Gamma-amino-n-butyric Acid (GABA)

<10

<10

<10

<10

Beta-aminoisobutyric Acid (bAib)

<1

<1

<1

<1

Alpha-amino-n-butyric Acid (Abu)

<21

<7

<5

<10

Hydroxylysine (Hyl)

<1

<1

<1

<1

Proline (Pro)

<14

<4

<4

<2

Ornithine (Orn)

<32

<15

<12

<15

Cystathionine (Cth)

<4

<1

<1

<2

Cystine (Cys)

<3

<3

<3

<3

Lysine (Lys)

16-67

17-41

13-45

23-54

Methionine (Met)

<19

<7

<5

<12

Valine (Val)

16-83

10-36

10-27

13-52

Tyrosine (Tyr)

<70

<22

<16

<65

Isoleucine (Ile)

2-30

2-14

3-11

3-17

Leucine (Leu)

14-72

9-25

8-23

10-53

Phenylalanine (Phe)

9-49

7-18

5-18

8-23

Tryptophan (Trp)

<14

<14

<14

<14

Allo-isoleucine (AlloIle)

<2

<2

<2

<2

 

All results reported in nmol/mL

Report Available

3 to 5 days

CPT Code Information

82139