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HelpTest Code CRSM Chromium, Serum
Additional Codes
| Mayo | CRS |
| Epic ID | LAB967 |
Special Instructions
Specimen Type
SerumOrdering Guidance
The US Food and Drug Administration recommended test for monitoring chromium in patients with metal-on-metal implants is CRWB / Chromium, Blood.
Specimen Required
Patient Preparation: High concentrations of gadolinium and iodine are known to potentially interfere with most inductively coupled plasma mass spectrometry-based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Supplies:
-Metal Free B-D Tube (No Additive), 6 mL (T184)
-Metal Free Specimen Vial (T173)
Collection Container/Tube: 6 mL Plain, royal blue-top Vacutainer plastic trace element blood collection tube
Submission Container/Tube: 7-mL Mayo metal-free, screw-capped, polypropylene vial
Specimen Volume: 1.6 mL Serum
Collection Instructions: See Metals Analysis Specimen Collection and Transport for complete instructions.
Collect 1.6mL Plain royal blue metal free serum. Spin down within 30 minutes and pour into metal free vial.
Specimen Minimum Volume
Serum: 0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | METAL FREE |
| Ambient | 28 days | METAL FREE | |
| Frozen | 28 days | METAL FREE |
Transport refrigerated in metal free vial.
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Method Name
Triple-Quadrupole Inductively Coupled Plasma-Mass Spectrometry (ICP-MS/MS)
Useful For
Screening for occupational exposure
Monitoring metallic prosthetic implant wear
Day(s) Performed
Monday through Friday
Report Available
1 to 4 daysReference Values
<0.4 ng/mL
When collected by a phlebotomist experienced in ultra-clean collection technique and handled according to the instructions in Metals Analysis Specimen Collection and Transport, we have observed the concentration of chromium in serum to be below 0.4 ng/mL. However, the majority of specimens submitted for analysis from unexposed individuals contain 0.1 ng/mL to 0.3 ng/mL of chromium. Commercial evacuated blood collection tubes not designed for trace-metal specimen collection yield serum containing 2.0 ng/mL to 5.0 ng/mL chromium derived from the collection tube.
CPT Code Information
82495