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Test Code CTDCM Connective Tissue Diseases Cascade, Serum

Additional Codes

Mayo CTDC
Epic ID LAB2375

 

Special Instructions

Specimen Type

Serum


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Information: Centrifuge and aliquot serum into plastic vial.


Specimen Minimum Volume

0.7 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 21 days
  Frozen  21 days
UPH Waterloo Region Lab Test Catalog Note:

Transport refrigerated.

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus OK

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Profile Information

Test ID Reporting Name Available Separately Always Performed
ANA2 Antinuclear Ab, S Yes Yes
CCP Cyclic Citrullinated Peptide Ab, S Yes Yes
IM_01 Interpretation No Yes

Testing Algorithm

If antinuclear antibodies are greater than or equal to 3.0 U, then antibodies to double-stranded DNA (dsDNA), extractable nuclear antigen evaluation, ribosome P, and centromere are performed at an additional charge.

 

For more information see Connective Tissue Disease Cascade.

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
CMA Centromere Ab, IgG, S Yes No
CASMT ANA2 Cascade No No
RIB Ribosome P Ab, IgG, S Yes No
ENAE Ab to Extractable Nuclear Ag Eval,S Yes No
ADNA1 dsDNA Ab, IgG, S Yes No

Useful For

Evaluation of patients with signs and symptoms compatible with connective tissue diseases

 

Initial evaluation of patients in clinical situations in which the prevalence of disease is low (6)

 

This test is not recommended for:

-Testing in clinical situations in which there is a high prevalence of connective tissue diseases (eg, rheumatology specialty practice)

-Follow-up evaluation of patients with known connective tissue diseases

Day(s) Performed

Monday through Saturday

Report Available

3 to 4 days

Reference Values

ANTINUCLEAR ANTIBODIES (ANA)

≤1.0 U (Negative)

1.1-2.9 U (Weakly positive)

3.0-5.9 U (Positive)

≥6.0 U (Strongly positive)

Reference values apply to all ages.

 

CYCLIC CITRULLINATED PEPTIDE ANTIBODIES, IgG

<20.0 U (Negative)

20.0-39.9 U (Weak positive)

40.0-59.9 U (Positive)

≥60.0 U (Strong positive) 

Reference values apply to all ages.

CPT Code Information

86038

86200

83516-Centromere (if appropriate)

83516-Ribosome (if appropriate)

86225-ds-DNA AB IgG, Serum (if appropriate)

86235 x 6-RNP, Sm, SS-B, SS-A, Jo 1, and Scl 70 (if appropriate)