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HelpTest Code HMGCRM 3-Hydroxy-3-Methylglutaryl Coenzyme-A (HMG-CoA) Reductase, Serum
Additional Codes
| Mayo | HMGCR |
| Epic ID | LAB3545 |
Specimen Type
SerumOrdering Guidance
NMS1 / Necrotizing Myopathy Evaluation, Serum is the preferred first tier test for identification of antibodies specific for necrotizing autoimmune myopathy (HMGCOA-IgG and SRP-IgG). This initial evaluation includes signal recognition particle (SRP) antibodies performed using tissue indirect immunofluorescence, which increases the clinical sensitivity as compared to SRP immunoblot methodologies.
Specimen Required
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 2 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 28 days |
| Frozen | 28 days | |
| Ambient | 72 hours |
Transport refrigerated.
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Method Name
Chemiluminescence Immunoassay (CIA)
Useful For
Evaluating patients with suspected necrotizing autoimmune myopathy
Measuring 3-hydroxy-3-methylglutaryl-CoA reductase antibodies
Day(s) Performed
Monday through Friday
Report Available
2 to 4 daysReference Values
<20.0 CU
CPT Code Information
82397