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HelpTest Code MDNS Methadone and Metabolites, Serum
Additional Codes
| Mayo | MDNS |
| Epic ID | LAB1054 |
Specimen Type
Serum RedSpecimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (Serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1.0 mL
Collection Instructions: Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days |
| Frozen | 28 days | |
| Ambient | 14 days |
UPH Waterloo Region Lab Test Catalog
Note:
Transport refrigerated.
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Useful For
Compliance monitoring of methadone
Assessment of methadone toxicity
Day(s) Performed
Tuesday, Thursday
Report Available
3 to 5 daysReference Values
Methadone:
Therapeutic: 100-400 ng/mL
Toxic: >2000 ng/mL
EDDP:
Not established
Cutoff concentrations by liquid chromatography tandem mass spectrometry:
Methadone: 10 ng/mL
EDDP: 5.0 ng/mL
CPT Code Information
G0480
80358 (if appropriate for select payers)